Protein Z-dependent protease inhibitor (ZPI) is a physiologically significant inhibitor of prothrombinase function
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منابع مشابه
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPI-binding...
متن کاملPolymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism.
Thromb Haemost 2006; 95: 909–10 Dear Sir, Protein Z-dependent protease inhibitor (ZPI), together with its cofactor protein Z (PZ), inhibits activated factor Xa (Xa) (1–3). Studies in mice showed that the PZ null genotype increases the mortality in utero of homozygous factor V Leiden mice due to vascular thrombosis and hepatic fibrin deposition (4), suggesting a role for the PZ-ZPI pathway in th...
متن کاملTHROMBOSIS AND HEMOSTASIS Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPIbinding ...
متن کاملThe protein Z/protein Z-dependent protease inhibitor complex.
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 but it has no enzymatic activity. It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces. In mice, the disruption of PZ or ZPI gene is asymptomatic, but enhances the thrombotic phenotype and mortality of other thro...
متن کاملIsolation of a protein Z-dependent plasma protease inhibitor.
Human protein Z (PZ) is a 62,000-Mr, vitamin K-dependent plasma protein whose structure is similar to coagulation factors VII, IX, X, protein C, and protein S, but whose function is not known. The procoagulant activity of factor Xa in a one-stage plasma coagulation assay is reduced when factor Xa is first incubated with PZ. This apparent inhibitory effect is time dependent, requires the presenc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.006787